Identified several genes frequently altered in peripheral T-cell lymphomas “of unclear origin”

This work has been published in the Proceedings of the National Academy of Sciences of the United States, the official journal of this Academy, and was carried out by a multi-centre group, including the laboratory of Dr. Xosé Bustelo of the Cancer Research Center (CIC-IBMCC) of Salamanca.

In a scientific article published this week, a multi-centre group with the participation of the laboratory of Dr. Xosé Bustelo of the Cancer Research Centre of Salamanca has reported the identification of several genes that are frequently altered in peripheral T-cell lymphomas of “unclear origin”. Among them is the proto-oncogene VAV1, which was found to be genetically altered (mutated) in 12% of the patients analysed. In the same study, alterations in this gene were also detected but with less frequency (3-7% of patients) in another related tumour, angioimmunoblastic T-cell lymphoma. Although it is epidemiologically less frequent, this tumour has malignant properties similar to those of peripheral T-cells.

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